Antiinflammatory activity of ethanol extracts of Hypericum perforatum L., H. barbatum Jacq., H. hirsutum L., H. richeri Vill. and H. androsaemum L. in rats |
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| Authors: | Savikin Katarina Dobrić Silva Tadić Vanja Zdunić Gordana |
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| Affiliation: | 1. Institute for Medicinal Plants Research, Tadeu?a Ko??uska 1, 11000 Belgrade, Serbia and MontenegroInstitute for Medicinal Plants Research, Tadeu?a Ko??u?ka 1, 11000 Belgrade, Serbia and Montenegro.;2. National Poison Control Center, Military Medical Academy, Crnotravska 16, 11000 Belgrade, Serbia and Montenegro;3. Institute for Medicinal Plants Research, Tadeu?a Ko??uska 1, 11000 Belgrade, Serbia and Montenegro |
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| Abstract: | Ethanol extracts of the aerial parts of six Hypericum species, H. barbatum, H. androsaemum, H. richerii, H. hirsutum, H. perforatum and H. perforatum cultivated on mountain Tara were tested for antiinflammatory activity in comparison with indomethacin (IND) using the carrageenan-induced rat paw edema test. It was found that all examined extracts produced antiinflammatory activity, particularly those from H. hirsutum, and both wild and cultivated H. perforatum. A dose-dependent antiinflammatory effect was especially pronounced in extracts showing some lower antiinflammatory activity. There was no correlation between the amount of hypericin in the extracts and their antiinflammatory activity. Copyright (c) 2006 John Wiley & Sons, Ltd. |
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| Keywords: | Hypericum species hypericin antiinflammatory activity indomethacin |
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