| 环磷酰胺及其制剂的二阶导数差示脉冲极谱法定量研究 |
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| 引用本文： | 梁云爱,李见春,门孝英. 环磷酰胺及其制剂的二阶导数差示脉冲极谱法定量研究[J]. 中国药学杂志, 2001, 36(9): 620-623 |
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| 作者姓名： | 梁云爱 李见春 门孝英 |
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| 作者单位： | 1. 山东省日照市药品检验所,
2. 山东省日照市人民医院, |
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| 摘 要： | 目的 建立环磷酰胺及其制剂的二阶导数差示脉冲极谱定量分析方法。方法 二阶导数差示脉冲极谱法。结果 环磷酰胺在乙醇-水(1∶9)的溶液中，于-0.101 V（vs Ag/AgCl）处出现一良好的二阶导数差示脉冲极谱峰，其峰幅值与环磷酰胺在 0.1～1.4 mmol·L-1范围内呈非常显著的线性关系（P＜0.01）, 检测限为9.0 nmol·L-1。结论 本法简便、快速、灵敏，结果准确。
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| 关 键 词： | 环磷酰胺 二阶导数差示脉冲极谱法 定量分析 |
| 文章编号： | 1001-2494(2001)09-0620-04 |
| 收稿时间： | 2000-04-19; |
| 修稿时间： | 2000-04-19 |
Studies on the quantitative determination of cyclophosphamide and its preparationby SDDPP |
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| LIANG Yun-ai ,LI Jian-chun ,MEN Xiao-ying. Studies on the quantitative determination of cyclophosphamide and its preparationby SDDPP[J]. Chinese Pharmaceutical Journal, 2001, 36(9): 620-623 |
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| Authors: | LIANG Yun-ai LI Jian-chun MEN Xiao-ying |
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| Affiliation: | LIANG Yun-ai 1,LI Jian-chun 2,MEN Xiao-ying 2 |
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| Abstract: | OBJECTIVE To develop an assay for the quantitative determination of the cyclophosphamide and its preparations.METHODS The Secondary derivative differential pulse polarography was developed. RESULTS There was a very good secondary derivative differential pulse polarogram Peak at -1.101 V (vs Ag/AgCl) in ethanol-water (1∶9) solution. The linear relationship between the concentrations of sulfadimidine sodium and the peak height was good over the range of 0.1～1.4 mmol·L-1(P＜0.01). The detective limit was 9.0 nmol·L-1.CONCLUSION The method is simple,accurate,rapid and sensitive. |
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| Keywords: | cyclophosphamide secondary derivative differentia l pulse polarography(SDDPP) quantitative determination |
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