Bioavailibility of paracetamol after oral administration to healthy volunteers |
| |
Authors: | J. J. Tukker J. M. A. Sitsen Ch. F. Gusdori |
| |
Affiliation: | (1) Department of Pharmaceutics, State University of Utrecht, Catharijnesingel 60, 3511 GH Utrecht, The Netherlands;(2) Department of Internal Medicine, Utrecht University Hospital, Catharijnesingel 101, 3511 GV Utrecht, The Netherlands;(3) Pharbita BV, C. van Uitgeeststraat 2, 1508 EH Zaandam, The Netherlands |
| |
Abstract: | The absorption rate and the bioavailability of two commercially available paracetamol tablets were investigated in a panel of seven volunteers; one of these tablets contained a combination of 50 mg caffeine and paracetamol. Considering the urinary excretion data, it is concluded that the tablets release their contents completely; the absolute bioavailability, however, calculated from plasma concentrations, is lower than 100%, indicating a first-pass effect. A marked interindividual variation in first-pass effect was noticed. No general influence of caffeine on the extent of absorption of paracetamol could be established; there is, however, a slightly positive influence of caffeine on the absorption rate of paracetamol in six out of seven volunteers. It was concluded that this positive influence on absorption rate is not responsible for the established enhancement of paracetamol analgesia by caffeine. |
| |
Keywords: | Administration, oral Bioavailability Caffeine Drug therapy, combination Paracetamol Pharmacokinetics |
本文献已被 SpringerLink 等数据库收录! |
|