| 食管癌p53、PCNA表达与局部体液免疫的关系 |
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| 引用本文： | 苏蔚,赵卫星,付华民,和瑞芝,卢朝晖,马力强. 食管癌p53、PCNA表达与局部体液免疫的关系[J]. 癌症, 2000, 19(2): 128-130 |
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| 作者姓名： | 苏蔚 赵卫星 付华民 和瑞芝 卢朝晖 马力强 |
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| 作者单位： | 河南新乡医学院病理教研室,河南,新乡,453003 |
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| 摘 要： | 目的：对８０例食管浸润癌组织中的局部体液免疫即ＩｇＧ、ＩｇＭ、ＩｇＡ产生细胞及Ｐ５３蛋白、ＰＣＮＡ进行检测，以探索局部体液免疫对抑癌基因突变及细胞增殖活性的影响。方法：采用直接免疫荧光染色法和Ｓ－Ｐ免疫组化染色法。结果：ＩｇＧ产生细胞与Ｐ５３蛋白，ＰＣＮＡ的表达呈负相关；ＩｇＧ阳性而Ｐ５３、ＰＣＮＡ阴性的病例，淋巴结转移及浸润的程度显著降低，ＩｇＡ、ＩｇＭ与Ｐ５３突变及ＰＣＮＡ的表达无关。结论：Ｉ
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| 关 键 词： | 食管肿瘤 p53基因 PCNA 体液免疫 |
| 修稿时间： | : |
Relationship between the local humoral immunity and the expression of p53, PCNA in esophageal carcinoma |
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| SU Wei,ZHAO Wei xing,FU Hua min,et al.. Relationship between the local humoral immunity and the expression of p53, PCNA in esophageal carcinoma[J]. Chinese journal of cancer, 2000, 19(2): 128-130 |
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| Authors: | SU Wei ZHAO Wei xing FU Hua min et al. |
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| Affiliation: | SU Wei,ZHAO Wei xing,FU Hua min,et al. Department of Pathology,XinXiang Medical College,Henan Province,Xinxiang 453003,P.R. China |
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| Abstract: | Objective: To probe the relationship between the local humoral immunity and the expression of p53,PCNA in esophageal carcinoma.Methods:Directimmunofluorescence and S P immunohistochemical assaies were applied to detect IgG , IgM ,IgA ,producing cells p53 protein and PCNA in 80 cases of esophageal invasive carcinoma.Results:There was a negative correlation between IgG producing cells and p53 or PCNA experiession,respectively.The tumor with IgG producing cells but loss of p53 and PCNA expression appeared less lymph node metastasis and tumor invasion.Conclusion:It seems that IgG could retain tumor matastasis and invasion through suppressing the p53 gene mutation and cell proliferation. |
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| Keywords: | Esophageal carcinoma IgG producing cell p53 PCNA |
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