霍奇金淋巴瘤病理特征分析

目的探讨淋巴结及肺霍奇金淋巴瘤(HL)的临床病理特征、免疫组化及鉴别诊断,提高HL病理诊断水平。方法对15例原发于淋巴结及1例原发于肺的HL进行组织形态学、免疫组织化学分析,并复习相关文献。结果发生于淋巴结者临床多为无痛性淋巴结肿大,发生于肺者表现咳嗽、咳痰。病理组织学类型:淋巴细胞为主型(LRCHL)8例,结节硬化型(NSHL)4例,混合细胞型(MCHL)3例,淋巴细胞消减型(LDHL)1例,未发现结节性淋巴结为主型。8例行免疫组化染色,肿瘤细胞CD15、CD30、CD20、CD68、CD79a阳性,CD45Ro阴性。结论霍奇金淋巴瘤是恶性淋巴瘤中的少见类型,临床表现多为无痛性淋巴结肿大,组织学改变复杂多样,应与慢性非特异性淋巴结炎、弥漫性大B细胞淋巴瘤(DLBL)及富于T细胞的B细胞淋巴瘤(TCRBCL)鉴别。

The clinicopathological features of Hodgkin lymphoma

Objective To study the clinical pathological characteristics,diagnosis and differential diagnosis in patients with Hodgkin lymphoma.Methods Fifteen patients with lymph node and one patient with primary Hodgkin lymphoma of lung were analyzed with histological and immunohistochemical staining and review of the related literature.Results 15 patients with Hodgkin lymphoma demonstrated painless lymph node.There were four pathological types: eight cases were nodular lymphocyte predominance(LRCHL),four cases were nodular sclerosis(NSHL),three cases were mixture cellularity(MCHL),the anther one was lymphocyte depletion(LDHL).The immunohistochemistry was performed in eight cases.The tumor cells expressed CD15,CD20,CD30,CD79 a and CD68.but it didn't expressed CD45RO.Conclusion Hodgkin lymphoma is a rare malignant tumor with difficulty in diagnosis.It should be differentiated from diffuse large B-cell lymphoma(DLDL) and T-cell rich B-cell lymphoma.