| 辐射诱导的旁观者效应研究进展 |
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| 引用本文： | 韦艳,吴冰,白海. 辐射诱导的旁观者效应研究进展[J]. 现代肿瘤医学, 2012, 20(1): 180-183. DOI: 10.3969/j.issn.1672-4992.2012.01.63 |
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| 作者姓名： | 韦艳 吴冰 白海 |
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| 作者单位： | 兰州军区兰州总医院血液病研究所,甘肃,兰州,730050 |
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| 基金项目： | 甘肃省中青年科技研究基金项目资助(编号:1007RJYA018) |
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| 摘 要： | 直接受到照射的细胞通过信号转导引起临近细胞的损伤,称为旁观者效应.其具体机制非常复杂,目前仍不完全清楚.本文从旁观者效应对细胞DNA损伤的类型,旁观者效应中的分子信号转导及体内存在的旁观者效应等不同方面进行综述.
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| 关 键 词： | 辐射 旁观者效应 DNA损伤 |
Advances of ionizing radiation-induced bystander effects |
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| WEI Yan,WU Bing,BAI Hai. Advances of ionizing radiation-induced bystander effects[J]. Journal of Modern Oncology, 2012, 20(1): 180-183. DOI: 10.3969/j.issn.1672-4992.2012.01.63 |
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| Authors: | WEI Yan WU Bing BAI Hai |
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| Affiliation: | Institute of Hematological Diseases,Lanzhou Military Area General Hospital,Gansu Lanzhou 730050,China. |
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| Abstract: | By stander effects means the induction of damage in neighboring non-hit cells by signals released from directly-irradiated cells.The mechanisms underlying bystander effects are complex and still not completely understood.In this review we describe different aspects of ionizing radiation-induced bystander effects: types of DNA damage,intercellular signals in bystander effects and bystander effects in vivo. |
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| Keywords: | ionizing radiation bystander effect DNA damage |
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