PTPN13和FAK在肺鳞癌中的表达及其临床意义

目的:研究PTPN13和FAK在肺鳞癌中的表达及意义,为建立早期预防、早期诊断、预后预警及个体化治疗的肺鳞癌防治新策略奠定基础.方法:免疫组化法观察PTPN13及FAK在肺鳞癌及癌旁组织中的表达情况.结果:PTPN13表达与肺鳞癌的临床分期、组织分化程度及淋巴结转移呈显著负相关(P<0.05);FAK表达与肺鳞癌的临床分期、组织分化程度及淋巴结转移呈显著正相关(P<0.05);PTPN13和FAK在肺鳞癌组织中的表达呈显著负相关(P<0.05).结论:PTPN13基因是肺鳞癌发生相关的抑癌基因,其抑制肿瘤侵袭转移的生物学功能可能与FAK磷酸化有关.

Expression of PTPN13 and FAK in lung squamous cell carcinoma and the clinical significance

Objective:To provide a basis for further mechanisms study,as well as for the development of a new strategy for prevention and therapy in lung cancer.Methods: Immunohistochemisty technology was applied to observe the expression of PTPN13 and FAK in lung squamous cell carcinoma tissues and adjacent normal lung tissues.Results: The positive expression rate of PTPN13 in lung squamous cell carcinoma was negatively associated with clinical stages,histodifferentiation and lymphatic metastasis(P<0.05).The positive expression rate of FAK in lung squamous cell carcinoma was positively associated with clinical stages,histodifferentiation and lymphatic metastasis(P<0.05).There was negative correlation between PTPN13 and FAK in lung squamous cell carcinoma(P<0.05).Conclusion: PTPN13 gene may be a tumor suppressor gene related with the carcinogenesis as well as the invasion and metastasis of lung squamous cell carcinoma.In the function of PTPN13 gene as a tumor suppressor gene in the carcinogenesis of lung squamous cell carcinoma,FAK gene phosphorylation may play important role.