代谢综合征患者血压晨峰与心脑血管事件的关系

目的 探讨代谢综合征患者血压晨峰现象(MBPS)与心脑血管事件的相关性.方法 选择112例代谢综合征患者采用动态血压监测仪记录24 h血压,血压晨峰值≥35 mmHg患者为晨峰组(MBPS组)45例,血压晨峰值＜35 mmHg患者为非晨峰组(NMBPS组)67例,两组均询问饮酒史、吸烟史、年龄、病程,测量诊室血压、身高、体重、计算体重指数(MBI),测定血糖、血脂,并对患者进行3年的随访.患者具备以下诊断标准为心脑血管事件:严重心律失常、急性冠脉综合征、缺血性脑血管病、出血性脑血管病,比较两组一般资料、动态血压各参数、心脑血管事件发生率.结果 与NMPBS组比较,MPBS组血压晨峰值、清晨平均动脉压、24 h平均收缩压、心脑血管事件发生率均明显升高,差异有统计学意义(P<0.05或P<0.01),晨峰组患者血压晨峰值与心脑血管事件发生率呈正相关.结论 代谢综合征患者血压晨峰与心脑血管事件发生密切相关,可能是心脑血管事件的独立危险因素.

Correlation between cardiovascular and cerebrovascular events and morning blood pressure surge in patients with metabolic syndrome

Objective To investigate the correlation between cardiovascular and cerebrovascular events and morning blood pressure surge(MBPS) in patients with metabolic syndrome.Methods A total of 112 patients with metabolic syndrome were divided into MBPS group(n=45,MBPS≥35 mmHg) and non-MBPS group(n=67,MBPS<35 mmHg) according to 24 h ambulatory blood pressure monitoring.All patients were investigated on drinking and smoking history,age,course of disease,blood pressure,height,weight,body mass index(MBI),glucose,blood lipid,and they were followed up for 3 years.General information,parameters of ambulatory blood pressure,incidence of cardiovascular and cerebrovascular events were compared between two groups.Results Compared with NMPBS group,MBPS,mean arterial pressure in the morning,24 h average systolic blood pressure,incidence of cardiovascular and cerebrovascular events in MBPS group significantly increased(P<0.05 or P<0.01).MBPS was positively correlated with incidence of cardiovascular and cerebrovascular events in MPBS group(r=0.8).Conclusion MBPS is closely correlated with incidence of cardiovascular and cerebrovascular events in patients with metabolic syndrome,and it may be an independent risk factor of cardiovascular and cerebrovascular events.