血清Mesothelin和CA125联合检测在上皮性卵巢癌诊断中的意义

目的:研究联合检测血清Mesothelin和CA125在上皮性卵巢癌诊断中的临床意义.方法:采用定量酶联免疫吸附试验(ELISA)检测上皮性卵巢癌患者31例,良性卵巢肿瘤32例和正常妇女30例血清中的Mesothelin和CA125水平.结果:上皮性卵巢癌患者的Mesothelin水平明显高于良性卵巢肿瘤患者和正常对照组(P<0.01),良性卵巢肿瘤组患者与正常对照组的差异无显著性(P>0.05).不同类型的上皮性卵巢癌的Mesothelin的差异无显著性(P>0.05).Mesothelin和CA125联合检测对上皮性卵巢癌诊断的灵敏度和正确率明显高于单项检测CA125或Mesothelin(P值均<0.05).结论:血清Mesothelin和CA125联合检测可提高上皮性卵巢癌的早期诊断率.

Significace of serum Mesothelin and CA125 in diagnosis of ovarian cancer

Objective:To determine the serum Mesothelin and CA125 in the diagnosis of ovarian cancer and analyze their clinical significance.Methods: The level of serum Mesothelin and CA125 was measured by ELISA including 31 ovarian cancer patients,32 benign ovarian tumor patients and 30 normal women.Results: Level of serum Mesothelin: ovarian cancer group was higher than that of the other two groups(P<0.01),there was no significant difference between the other two groups(P>0.05),also there was no significant difference among the dinfferent kinds of ovarian cancer(P>0.05).Sensitivity and accuracy of the combination of serum Mesothelin and CA125 in ovarian cancer: were higher than detection of CA125 alone(P<0.05),or Mesothelin alone(P<0.05).Conclusion: The level of serum Mesothelin combined with CA125 can promote the diagnosis of ovarian cancer.