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恶性胸腔积液不同热化疗灌注模式的疗效比较
引用本文:郭海周,李谦平,王建军,周福有,李英,孟丽杰. 恶性胸腔积液不同热化疗灌注模式的疗效比较[J]. 现代肿瘤医学, 2012, 20(1): 78-80. DOI: 10.3969/j.issn.1672-4992.2012.01.25
作者姓名:郭海周  李谦平  王建军  周福有  李英  孟丽杰
作者单位:1. 华中科技大学同济医学院附属协和医院,湖北,武汉,430022;安阳市肿瘤医院,河南,安阳,455000
2. 华中科技大学同济医学院附属协和医院,湖北,武汉,430022
3. 安阳市肿瘤医院,河南,安阳,455000
基金项目:湖北省教育厅科学技术研究项目(B20112116)
摘    要:目的:探讨最佳胸腔热化疗灌注模式.方法:49例合并恶性胸腔积液的肺癌患者接受了胸腔热化疗灌注,依治疗模式分为手术组(手术切除病变,术后连续灌注),循环灌注组(胸腔闭式引流术,术后循环灌注)和非循环灌注组(胸腔穿刺术,术后保留灌注后持续引流).比较不同组别的治疗效果.结果:手术组18例胸腔积液全部得到控制,循环灌注组及非循环灌注组中各有1例(1/8),7例(7/23)未控,治疗所需时间分别为(5.56±1.01)天,(8.8±2.32)天和(9.86±5.88)天.结论:胸腔内热化疗灌注的治疗模式以手术切除病变后连续循环灌注为佳.

关 键 词:胸腔积液  手术  胸腔热灌注

Comparison of different model for pleural hyperthermic chemoperfusion
GUO Haizhou,LI Qianping,WANG Jianjun,ZHOU Fuyou,LI Ying,MENG Lijie. Comparison of different model for pleural hyperthermic chemoperfusion[J]. Journal of Modern Oncology, 2012, 20(1): 78-80. DOI: 10.3969/j.issn.1672-4992.2012.01.25
Authors:GUO Haizhou  LI Qianping  WANG Jianjun  ZHOU Fuyou  LI Ying  MENG Lijie
Affiliation:1Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Hubei Wuhan 430022,China;2Anyang Tumor Hospital,Henan Anyang 455000,China.
Abstract:Objective:To explore the optimal strategy of pleural hyperthermic chemoperfusion.Methods: All 49 patients of lung cancer with malignant pleural effusions who underwent pleural hyperthermic chemoperfusion were divided into operation group(lesion resection and continual perfusion),circular perfusion group(thoracic drainage and circular perfusion) and non-circulating perfusion group(thoracentesis,retention perfusion then drainage).Their therapeutic effects were compared.Results:Pleural effusion in operation group were all controlled within 5.56±1.01 days,while 1 in circular group(1/8) and 7 in non-circulating perfusion group(7/23) failed.The average time needed for effusion controlling were 8.8±2.32 and 9.86±5.88 days in the later two groups.Conclusion: Continual and circular perfusion following operation is the recommended model of pleural hyperthermic perfusion chemotherapy.
Keywords:pleural effusion  surgery  pleural hyperthermic perfusion chemotherapy
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