膀胱尿路上皮癌中FHIT的表达及其与预后的关系

目的 探讨膀胱尿路上皮癌中脆性组氨酸三联体(FHIT)蛋白的表达状况与临床预后的关系.方法 利用免疫组织化学SP法检测62例膀胱尿路上皮癌和35例正常膀胱组织中FHIT蛋白的表达,并对62例膀胱癌进行随访,对其随访资料进行Kaplan-Meier生存分析.结果 膀胱尿路上皮癌FHIT蛋白表达的阳性率为41.94%(26/62);正常膀胱组织为97.14%(34/35);FHIT蛋白表达的阳性率在癌组织分级中Ⅰ级癌中为54.05%(20/37),Ⅱ-Ⅲ级癌24.00%(6/25);FHIT蛋白表达的阳性率在病理分期Tis-T1和T2-T4分别是46.15%(18/39)和34.78%(8/23);各组间比较差异均有统计学意义(P<0.05).在膀胱尿路上皮癌的5年随访中,FHIT蛋白表达阳性与阴性的存活率分别为47.16%和52.83%,两组间比较差异有统计学意义(P<0.05).结论 FHIT蛋白表达与膀胱尿路上皮癌组织学分级、病理分期及5年存活率密切相关,提示FHIT在膀胱尿路上皮癌的演化和进展过程中起着重要作用.

Expression of fragile histidine triad in bladder carcinoma and its relation to prognosis

Objective To investigate the expression of fragile histidine triad(FHIT) protein and its relationship with the prognosis in the bladder urothelial carcinoma.Methods Expression of FHIT protein was detected using immunohistochemical SP in 62 cases of bladder uroepthelial carcinoma tissues and 35 cases of normal bladder tissues.All 62 patients with bladder cancer were followed up.The data was analyzed by Kaplan-Meier survival analysis.Results Positive rate of FHIT protein expression was 41.94%(26/62)and 97.14%(34/35) in bladder uroepthelial carcinoma and normal bladder tissues,respectively.Positive rate of FHIT protein expression was 54.05%(20/37)for gradeⅠ,24.00%(6/25)for gradeⅡ-Ⅲ.FHIT protein expression positive rate for Tis-T1 and T2-T4 were 46.15%(18/39) and 34.78%(8/23),respectively.The difference in positive rate of FHIT protein expression was statistically significant between two groups(P<0.05).After followed-up for five years,survival rates were 47.16% and 52.83% in FHIT protein positive and negative patients(P<0.05).Conclusion The results suggest that FHIT protein may play an important role in evolution and progress of bladder uroepthelial carcinoma.