B cell commitment. |
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| Authors: | C J Paige A Cumano G E Wu |
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| Affiliation: | Division of Cell and Molecular Biology, Ontario Cancer Institute, Toronto, Canada. |
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| Abstract: | Multipotential stem cells have the capacity to differentiate into a variety of cell types including B lymphocytes. The development of B cells from multipotential progenitors has been the subject of numerous studies and many aspects of this transition are well characterized. However, the initial genetic events which commit a stem cell to follow the B lineage developmental pathway have not yet been discovered. In this review we examine diverse experiments which may lead to increased understanding of the important first steps in the commitment process. |
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