Successful reduced intensity allogeneic stem cell transplantation for systemic AL amyloidosis |
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Authors: | Imamura Tomoyuki Ogata Masao Kohno Kazuhiro Tomo Tadashi Ohtsuka Eiichi Kikuchi Hiroshi Kadota Jun-ichi |
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Institution: | Division of Pathogenesis and Disease Control, Department of Infectious Diseases, Oita, Japan. tomo3jo@oct-net.ne.jp |
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Abstract: | No established treatments for systemic AL amyloidosis have been determined, and only four reports have described allogeneic stem cell transplantation for this disease. We report the case of a patient with orthostatic hypotension, diarrhea, nephrotic syndrome, and cardiac amyloidosis due to systemic AL amyloidosis. Reduced intensity allogeneic stem cell transplantation (RIST) was performed using a conditioning regimen comprising fludarabine 125 mg/m2 and melphalan 90 mg/m2. Hematologically complete remission and symptomatic improvement were obtained without severe transplantation-related complications. RIST may thus offer a useful treatment strategy for systemic AL amyloidosis complicated by cardiac amyloidosis. |
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Keywords: | systemic AL amyloidosis reduced intensity allogeneic stem cell transplantation |
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