Hypercalcemia and 13-cis-retinoic acid in post-consolidation therapy of neuroblastoma |
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Authors: | Marabelle Aurélien Sapin Vincent Rousseau Raphaël Periquet Brigitte Demeocq François Kanold Justyna |
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Institution: | Centre Léon Bérard, Institut d'Hématologie et d'Oncologie Pédiatrique, F-69008 Lyon, France. marabell@lyon.fnclcc.fr |
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Abstract: | We report 19 episodes of hypercalcemia in three children treated with 13-cis-retinoic acid (13-cis-RA) as a post-consolidation therapy for high-risk neuroblastoma. There was no concomitant overload in 13-cis-RA blood levels. Blood calcium fell after arrest of 13-cis-RA intake. Half dosage retinoid treatment resumption did not prevent the recurrence of hypercalcemia. Concomitant biological values showed massive bone resorption. Hence, hypercalcemia seemed not secondary to 13-cis-RA overload but rather to inter-individual variability in its interaction with bone metabolism. Current guidelines in case of hypercalcemia are to reduce 13-cis-RA dosage. Instead we propose to maintain the therapeutic dosage, but to shorten the duration of courses. |
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Keywords: | 13‐cis‐retinoic acid hypercalcemia neuroblastoma |
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