| 藁本内酯脂质体制备工艺的研究 |
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| 引用本文： | 李志浩,李鹏,朱雪松,郑芳.藁本内酯脂质体制备工艺的研究[J].中草药,2010,41(4):564-568. |
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| 作者姓名： | 李志浩 李鹏 朱雪松 郑芳 |
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| 作者单位： | 郧阳医学院附属东风医院,药剂部,湖北,十堰,442008 |
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| 摘 要： | 目的 研究藁本内酯脂质体最佳制备工艺及处方.方法 采用乙醇注入法制备藁本内酯脂质体,以包封率为评价指标,采用正交设计优化处方和制备工艺,高效液相色谱法测定其包封率.结果 最佳工艺处方为:藁本内酯与卵磷脂的比例为1:10,卵磷脂与胆固醇的质量比为2:1,PBS缓冲溶液pH为7.5,制备温度为35℃.结论 经优化得到的藁本内酯脂质体处方合理,工艺可行.
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| 关 键 词： | 藁本内酯 脂质体 制备工艺 |
| 收稿时间： | 2009/8/11 0:00:00 |
Research on preparation technology of ligustilide liposomes |
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| LI Zhi-hao,LI Peng,ZHU Xue-song and ZHENG Fang.Research on preparation technology of ligustilide liposomes[J].Chinese Traditional and Herbal Drugs,2010,41(4):564-568. |
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| Authors: | LI Zhi-hao LI Peng ZHU Xue-song and ZHENG Fang |
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| Institution: | Department of Pharmacy, Dongfeng General Hospital Affiliated to Yunyang Medical College, Shiyan 442008, China;Department of Pharmacy, Dongfeng General Hospital Affiliated to Yunyang Medical College, Shiyan 442008, China;Department of Pharmacy, Dongfeng General Hospital Affiliated to Yunyang Medical College, Shiyan 442008, China;Department of Pharmacy, Dongfeng General Hospital Affiliated to Yunyang Medical College, Shiyan 442008, China |
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| Abstract: | |
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| Keywords: | ligustilide liposomes preparation technology |
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