鼻腔原发性恶性黑色素瘤8例病理分析

本文报告了8例鼻腔原发性恶性黑色素瘤，其细胞形态及组织结构复杂多样。其中4例为无色素型，2例初诊为其他肿瘤。经免疫组化检查证实8例均为恶性黑色素瘤。免疫组化检测结果为：HMB45（8／8），vimentin（8／8），S－100（8／8），NSE（5／8），LC（0/8）。我们体会在高度怀疑鼻腔恶性黑色素瘤时，可通过HMB45及vimentin、S－100、NSE、LCA等的联合标记进行诊断及鉴别诊断。

Pathologic analysis of 8 cases with primary nasal malignant melanoma

8 cases of primary nasal malignant melanoma whose histological patterns and cytological morphosis werevarious were reported. 4 cases of them were amelanotic type and 2 cases were misdiagnosed.as other tumors. All ofthe eight cases were confirmed as malignant melanoma by immunohistoc be mis try. Immunostainings were positivefor HMB45 (8/8), vimentin (8/8), S - 100 (8/8), NSE (5/8). All cases were negative for LCA. The results suggest that the diagnosis and differential diagnosis be made by multi -labelling with HMB45, vimentin, S-100,NSE and LCA when the tumors are highly suspected of primary nasal mucosal malignant melanoma.