Controlled release of antiseptic drug from poly(3-hydroxybutyrate)-based membranes. combination of diffusion and kinetic mechanisms

A polymeric system based on biocompatible and biodegradable poly(3-hydroxybutyrate) (PHB) is proposed for controlled release of furacilin (Frc). The kinetics of Frc release from PHB membranes containing 0.5–5.0 wt% Frc into a model aqueous medium at 25°C have been studied using a UV spectroscopy technique. The drug release profiles present a combination of diffusion and kinetic components. The diffusion component of the release kinetics has been analyzed and the dependence of the diffusivity on the drug concentrations has been determined. The rate constant of the release kinetics depends on the Frc concentration and is related to the hydrolytic destruction of PHB. The PHB hydrolysis is most clearly demonstrated in long-term experiments (after the first week of drug release). The obtained results are useful for the development of new controlled drug delivery systems containing several drugs, which provide a combined action on tissues and organs of the organism. __________ Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 41, No. 12, pp. 30–33, December, 2007.