| 慢性酒精性肝病动物模型的研究 |
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| 引用本文： | 肖洪彬,姚凤云,穆欣,段富津. 慢性酒精性肝病动物模型的研究[J]. 中国中医药信息杂志, 2006, 13(10): 32-33 |
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| 作者姓名： | 肖洪彬 姚凤云 穆欣 段富津 |
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| 作者单位： | 黑龙江中医药大学实验中心,黑龙江,哈尔滨,150040 |
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| 摘 要： | 目的研究与人类酒精性肝病发病过程相似的实验动物模型。方法给大鼠连续灌服纯粮食酒13周,取血和肝组织做谷草转氨酶(AST)、谷丙转氨酶(ALT)等血清生化学指标和丙二醛(MDA)等脂质过氧化物检测及肝组织病理学检测。结果大鼠血清ALT、AST、MDA的含量显著增高,血清白蛋白(ALB)明显降低;病理学结果显示,每只饮酒大鼠均出现程度不同的肝细胞脂肪变性。结论长期大量饮酒所造动物模型比较成功,可以用其对酒精性肝病进行研究。
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| 关 键 词： | 酒精性肝病 动物模型 |
| 文章编号： | 1005-5304（2006）10-0032-02 |
| 收稿时间： | 2006-03-07 |
| 修稿时间： | 2006-03-07 |
Study on Chronic Alcoholic Liver Disease Model of Rats |
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| XIAO Hong-bin, YAO Feng-yun, MU Xin, et al. Study on Chronic Alcoholic Liver Disease Model of Rats[J]. Chinese Journal of Information on Traditional Chinese Medicine, 2006, 13(10): 32-33 |
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| Authors: | XIAO Hong-bin YAO Feng-yun MU Xin et al |
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| Affiliation: | Experiment Center of Heilongjiang University of TCM, Haerbin 150040, China |
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| Abstract: | Objective To establish alcoholic liver disease (ALD) model of rats. Method Rats were given wine by ig for 13 weeks. ALD were assessed by the level of serum glutamic-pyruvic transaminase (ALT), glutamic oxalacetic transaminase (AST), malonaldehyde (MDA) and pathological changes of liver. Result Over-dose wine can increase the level of serum ALT, AST, and MDA, decrease the level of serum albumin (ALB), and induce hepatic steatosis. Conclusion Alcoholic liver disease model of rats can be established by long-time and over-dose wine. The model can be applied in the research of ALD. |
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| Keywords: | alcoholic liver disease animal model |
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