| 银屑病患者外周血白细胞磷酸二酯酶活性检测及临床意义 |
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| 引用本文： | 夏天保,吕世超,路浩军. 银屑病患者外周血白细胞磷酸二酯酶活性检测及临床意义[J]. 实用皮肤病学杂志, 2012, 5(2): 74-75 |
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| 作者姓名： | 夏天保 吕世超 路浩军 |
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| 作者单位： | 1. 解放军306医院皮肤科,北京,100101
2. 解放军306医院中心实验室,北京,100101 |
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| 摘 要： | 目的通过检测正常人群和银屑病患者外周血白细胞磷酸二酯酶（phosphodiesterase，PDEs）活性，探讨PDEs活性在银屑病发病中的作用。方法对50例银屑病患者及60名健康对照者外周血白细胞应用高效液相色谱法（HPLC）检测PDEs活性。结果银屑病患者外周血白细胞PDEs活性为（10．40±3．54）％，健康对照者为（8．60±2．25）％，两者差异有统计学意义（P〈0．05）。结论外周血白细胞PDEs活性与银屑病的发病可能具有相关性。
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| 关 键 词： | 银屑病 磷酸二酯酶 高效液相色谱法 |
The detection and clinical significance of the PDEs activities in psoriasis patients |
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| XIA Tian-bao , LV Shi-chao , LU Hao-jun. The detection and clinical significance of the PDEs activities in psoriasis patients[J]. Journal of Practical Dermatology, 2012, 5(2): 74-75 |
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| Authors: | XIA Tian-bao LV Shi-chao LU Hao-jun |
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| Affiliation: | Department of Dermatology, 306th Hospital of PLA, Beijing 100101, China |
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| Abstract: | Objective To Investigate whether the PDEs activities is abnormal or not in psoriasis patients by detecting the PDEs activities of both psoriasis patients and healthy controls, and explore the potential role of PDEs activities changes in the pathogenesis of psoriasis. Methods PDEs activities were detected by using high performance liquid chromatography(HPLC) in 50 patients with psoriasis and 60 healthy controls. Results The PDEs activities is 10.40%±3.54% in psoriasis patients,and 8.60%±2.25% in the healthy controls. The PDEs activities in patients with psoriasis is significant higher than that in the controls (P<0.05). Conclusions The PDEs activities may be a risk factor for psoriasis. |
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| Keywords: | Psoriasis Phosphodiesterase HPLC |
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