唑来膦酸致全身皮疹

1例57岁女性患者因重度骨质疏松症给予碳酸钙和骨化三醇口服,1周后,给予唑来膦酸5 mg溶于0.9%氯化钠注射液100 ml静脉滴注。第2天,患者出现发热、全身皮疹,头晕、乏力、关节疼痛及双下肢肌肉酸痛。立即给予地塞米松、氯雷他定。第7天,患者头晕、乏力、关节疼痛及双下肢肌肉酸痛等症状消失,体温降至正常。第10天皮疹完全消退。

Generalized skin rash due to zoledronic acid

A 57-year-old woman received oral calcium carbonate and calcitriol for severe osteoporosis.One week later,an IV infusion of zoledronic acid 5 mg dissolved in 0.9% sodium chloride solution 100 ml was given.On day 2,she developed fever,generalized skin rash,dizziness,asthenia,as well as joint pain and muscle aches in her lower limbs.She was given dexamethasone and loratadine immediately.On day 7,her clinical symptoms such as dizziness,asthenia,as well as joint pain and muscle aches in her lower limbs disappeared,and her body temperature returned to normal.On day 10,her skin rash completely disappeared.