择期冠脉支架置入术对急性心肌梗死患者血清细胞色素C水平的影响

目的：观察择期冠状动脉支架置入术对急性心肌梗死（AMI）患者血清细胞色素C（Cyt C）水平的影响。方法：入选AMI并于梗死后10-14d行冠状动脉支架置入术的患者30例作为AMI组;另选择经冠脉造影排除冠心病（CHD）的患者30例作为非CHD对照组,采用酶联免疫吸附（ELISA）方法测定患者在冠状动脉支架置入术前,术后48h、72h血清Cyt C浓度。结果：1.冠脉支架置入术前AMI组血清Cyt C水平显著高于非CHD对照组[（1.18±0.71）ng/ml比（0.25±0.03）ng/ml,P〈0.01];2.冠状动脉支架置入术后48h、72h血清Cyt C水平[（0.68±0.29）ng/ml、（0.66±0.25）ng/ml]显著低于冠状动脉支架置入术前（P〈0.01）。结论：择期冠脉支架置入术能改善急性心肌梗死患者心肌细胞的凋亡。

Influence of delayed percutaneous coronary intervention on serum level of cytochrome C in patients with acute myocardial infarction

Objective: To observe influence of delayed percutaneous coronary intervention(PCI) on serum level of cytochrome C(Cyt C) in patients with acute myocardial infarction(AMI).Methods:A total of 30 AMI patients undergoing PCI on 10~14d after myocardial infarction were regard as AMI group;another 30 patients excluded coronary heart disease(CHD) by coronary angiography were treated as non-CHD control group.Enzyme linked immunosorbent assay(ELISA) was used to measure serum concentration of Cyt C before,48h and 72h after PCI.Results:1.Serum level of Cyt C in AMI group before PCI was significantly higher than that of non-CHD control group [(1.18±0.71) ng/ml vs.(0.25±0.03) ng/ml,P<0.01];2.serum levels of Cyt C in AMI group on 48h and 72h after PCI [(0.68±0.29) ng/ml,(0.66±0.25) ng/ml]were significantly lower than that of before PCI(P<0.01).Conclusion: Delayed percutaneous coronary intervention can improve apoptosis of myocardial cells in patients with acute myocardial infarction.