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Serum glycylproline p-nitroanilidase activity in rheumatoid arthritis and systemic lupus erythematosus |
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| Authors: | K. Fujita M. Hirano J. Ochiai M. Funabashi I. Nagatsu T. Nagatsu S. Sakakibara |
| Affiliation: | 1. Institute for Comprehensive Medical Science, Department of Internal Medicine, and Department of Anatomy, School of Medicine, Fujita-Gakuen University, Toyoake, Aichi, 470-11 Japan;2. Laboratory of Cell Physiology, Department of Life Chemistry, Graduate School at Nagatsuta, Tokyo Institute of Technology, Yokohama, 227 Japan;3. Peptide Institute, Protein Research Foundation, Minoh, Osaka, 562 Japan |
| Abstract: | Glycylproline p-nitroanilidase activity in serum of patients with advanced rheumatoid arthritis or with systemic lupus erythematosus but with normal hepatic function was found to be significantly lower than that of normal adult controls. Decrease of this enzyme's serum activity was more pronounced in systemic lupus erythematosus. A significant inverse correlation was observed between the enzyme activity and the duration of rheumatoid arthritis. |
| Keywords: | To whom correspondence should be addressed. |
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