新疆哈萨克族、汉族食管癌组织中c-erbB-2、p53蛋白的表达及其临床病理学意义

目的:探讨c-erbB-2、p53蛋白在新疆哈萨克族、汉族食管癌组织中的表达与食管癌临床病理指标的关系以及c-erbB-2与p53表达的相关性。方法:应用免疫组化S-P法测定8l例哈萨克族、汉族食管鳞状细胞癌石蜡包埋组织和30例癌旁正常食管组织中c-erbB-2、p53的蛋白表达。结果:在81例食管癌中,c-erbB-2和p53阳性表达率分别为87.65%、68.14%,二者在民族间的阳性表达率无统计学差异(P>0.05),但c-erbB-2、p53在癌旁正常食管组织中的阳性表达率分别为23.33%、36.67%,与癌组织间存在统计学差异(P<0.05)。随着浸润深度增加及病程进展,c-erbB-2、p53的阳性表达率明显上升。c-erbB-2表达与肿瘤细胞分化程度、浸润深度、临床分期及年龄有关(P<0.05),p53表达与肿瘤浸润深度及临床分期有关(P<0.05)。结论:c-erbB-2、p53在食管癌的发生、发展中呈高表达,且与恶性肿瘤的侵袭及临床分期有关,可作为预测食管癌临床预后的分子指标。

Expression of c-erbB-2 andp53protein in tumor tissues of Kazak and Han patients with esophagealcarcinoma inXinjiang and its clinicopathologicalsignificance

Objective: In order to understand the clinicopathological significance of multiple genes alteration in esophageal carcinoma tissues of Kazak and Han patients in Xinjiang. Methods: The c-erbB-2 and p53 protein expression in 81 specimens of esophageal carcinoma tissues and non-tumor 30 specimens were examined by immunohistochemical S-P technique. Results: The positive frequency of c-erbB-2 and p53 protein were 87.56% and 68.14% in tumor tissues respectively.There was no statistic significance of c-erbB-2 and p53 immunocreacitivity in tumor tissues between Kazak and Han patients was found P>0.05,but c-erbB-2 and p53 were significant high thannon-tumor tissues P0.05.Expression of c-erbB-2 and p53 protein were increasing in the process of the development of these lesions. There were close relations both c-erbB-2 and p53 protein expression in the depth of tumor invasion and clinical course was found P0.05.Also,Expression of c-erbB-2 protein was related with histologic grade 0f tumor P0.05. Conclusion: c-erbB-2 and p53 protein have higher expression in the occur and development of esophageal carcinoma tissues.and they have related to tumor invasion and clinical course,and they could be identified as molecular markers for clinical prognosis of the esophageal carcinoma.