胎肝细胞悬液输注治疗某些血液病前后血象及临床观察

用自身对比法分析观察血液病46例,FLI30例次治疗前后血象及临床疗效。化疗组FLI后两周WBC及BPC上升20％以上者分别为75％及70.3％;与自身单纯化疗相比相差非常显著(P<0.001);但Ret改变不明显。升血药组中急性粒缺疗效显著迅速,纯红再障一例经自身FLI后缓解两年未复发。AMF一例FLI17次仅有短暂血象改善,后加用维生D_3治疗后缓解15个月。慢性再障,难治性贫血及ITP疗效不显著不持久。FLI的细胞数量与疗效无明显相关、供受者ABO血型不同的FLI无不良反应。FLI疗效机制中体液因素比细胞因素似更重要。

Hemogram and Clinical Observation before and after FetalLiver Cell Suspension Infusion in the Treatmentof Some Hematological Diseases

Recent change of blood pictures by self-control and clinical observation before and after fetal liver cell suspension infusion (FLI) in the treatment of 46 patients with hematological diseases for 130 person-times in recent two years were reported.There were 64 episodes fo FLI in chemotherapy group. Two weeks after FLI, WBC and BPC rose quickly to more than 20% in 75% and 70% of cases respec-were significant differences of WBC and BPC when compared to the self-control group with chemotherapy only(P<0.001),but the change of reticulocytes tively. There was mild. The clinical condition, hemogram and marrow picture of two patients with refractory ALL in the late improved by FLI after the lash-chemotherapy with high dosage (1000mg) of MTX. FLI could also rise blood pictures in the group of hematic tonic diseases after no cure of conventional treatment. Among those, the therapuetc effect of FLI for acute, agranulocytosis was dramatic and rapid. It is possible that FLI play a role of peculiar effect.One out of 3 cases with pure red cell aplasia returned to remission for 25 months after self-FLI. It seems the autogenic FLI is more efficient than allogenic FLI. A patient with acute myelofibrosis was treated with routine cure and FL1 of 17 times for 20 months, his blood picture revealed mild temporary improvement, while he returned to marked remission after the treatment with vitamin D3. It showed that FLI cooperate with relative cure would make more efficienty.The response of FLI in aplastic anemia, refractory anemia and idiopathic thrombocytopenic purpura was not marked and persistent. This results may relate to their special pathogenesis.The number of infusion cells and ABO blood group were not relate to thera-puetic effect. The different blood group between the donor and recipient for FLI is safe and no side effect. We infer that hormonal factors are seemingly more important than cell factors in the major mechanism of FLI effect.