Antibodies against copper-oxidised and malondialdehyde-modified low density lipoproteins in pre-eclamptic pregnancies |
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Authors: | Jukka Uotila Consultant Tiina Solakivi Research Scientist Olli Jaakkola Senior Lecturer † Risto Tuimala Senior Lecturer Terho Lehtimaki Senior Lecturer † |
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Institution: | Departments of Obstetrics and Gynaecology, Tampere University Hospital;Departments of Clinical Chemistry and Research Laboratory for Atherosclerosis, Tampere University Hospital;Department of Medical Biochemistry, Medical School, University of Tampere, Finland |
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Abstract: | Objective To measure auto-antibodies against oxidatively modified low density lipoprotein (LDL) in pre-eclamptic pregnancies using two different techniques. Design Clinical study comparing pre-eclamptic and normal pregnancies. Setting Tampere University Hospital, Finland. Population Twenty-one primigravidae with pre-eclampsia and 13 healthy, normotensive primigravidae as controls. Methods The serum titers of antibodies against both malondialdehyde-modified and copper-oxidised LDL (MDA-LDL and copper-ox LDL) were analysed and related to parameters reflecting the severity of pre-eclampsia. Results There was a positive correlation ( r = 0.58 ) between antibodies against MDA-LDL and copper-ox LDL in women with pre-eclampsia but not in healthy pregnant controls. The antibody levels against copper-ox LDL, but not against MDA-LDL, were higher in women with pre-eclampsia than in women with a normal pregnancy ( P < 0.01 ). While the antibody titers against copper-ox LDL did not correlate with any parameter reflecting the severity of pre-eclampsia, those against MDA-LDL showed a positive correlation with the level of diastolic blood pressure ( r = 0.54 ) and a negative correlation with platelet count ( r = 461 ) in women with pre-eclampsia. Conclusions There are increased titers of serum autoantibodies against copper-oxidised LDL in pre-eclampsia, which may reflect enhanced lipid peroxidation involving circulating lipoproteins. |
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