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经皮肺穿刺近距离放射治疗肺癌的疗效观察
引用本文:王静,李振家,王显锋,明德国,迟翔宇. 经皮肺穿刺近距离放射治疗肺癌的疗效观察[J]. 山东大学学报(医学版), 2006, 44(10): 1017-1020
作者姓名:王静  李振家  王显锋  明德国  迟翔宇
作者单位:山东大学山东省立医院呼吸科,山东,济南,250021;山东省医学影像学研究所,山东,济南,250021
基金项目:山东省卫生厅保健处资助项目
摘    要:目的:探讨CT导向下经皮肺穿刺125I粒子近距离放疗对肺癌的近期疗效。方法:对53例肺癌患者在CT导向下经皮肺穿刺,瘤体内植入125I粒子。观察手术前后局部肿瘤大小、血常规、肝肾功能及免疫指标的变化。结果:对62个病灶行81次穿刺,术后1、2、3、6个月原发部位肿瘤治疗有效率分别为33.87%(21/62)、51.61%(32/62)、91.94%(57/62)、95.16%(59/62)。外周血常规、肝肾功能、免疫功能等指标手术前后无明显变化。5例出现气胸(6.17%),9例发生咳血(11.11%)。植入后第6个月2例患者出现粒子丢失。结论:CT导向下经皮肺穿刺125I粒子近距离放疗对肺癌局部控制率高,对血常规、肝肾功能、免疫功能无明显影响,是一种疗效确切、安全简便的肿瘤微创治疗技术。

关 键 词:碘-125  近距离放疗  肺肿瘤
文章编号:1671-7554(2006)10-1017-04
收稿时间:2006-07-10
修稿时间:2006-07-10

Brachytherapy by CT-guided percutaneous paracentesis implantation of iodine-125 seeds for lung cancer
WANG Jing,LI Zhen-jia,WANG Xian-feng,MING De-guo,CHI Xiang-yu. Brachytherapy by CT-guided percutaneous paracentesis implantation of iodine-125 seeds for lung cancer[J]. Journal of Shandong University:Health Sciences, 2006, 44(10): 1017-1020
Authors:WANG Jing  LI Zhen-jia  WANG Xian-feng  MING De-guo  CHI Xiang-yu
Affiliation:1. Department of Respiratory Diseases, Shandong Provincial Hospital, Shandong, University, Jinan 250021, Shandong, China; 2. Shandong Institute of Medical Imaging, Jinan 250021, Shandong, China
Abstract:Objective: To explore the clinical value of ~(125) I interstitial brachytherapy by CT-guided percutanepus paracentesis.Methods: Implantation of iodine-125 seeds with implanting needle(18-gauge) by optical navigating system was carried out in fifty-three patients with lung cancer.After operation,the size of tumors and the changes of blood were observed.Results: The fifty-three patients,with sixty-two focuses,were given eighty-one punctures and observed for more than six months.Twelve of the patients were implanted again.The response rate of one,two,three and six months after operation was 33.87%(21/62),51.61%(32/62),91.94%(57/62) and 95.16%(59/62) respectively.There were no significant changes in peripheral blood cells,liver functions,renal functions,T cell subgroups and the activity of natural killer cells after operation.Pneumothorax and hemoptysis were seen in 5(6.17%,5/81) and(9(11.11%,)9/81) patients respectively.Conclusion: Brachytherapy by CT-guided percutaneous paracentesis implantation of iodine-125 seeds is effective and safe for the treatment of lung cancer.The complication is rare and easy to treat.
Keywords:Iodine-125  Brachytherapy  Lung neoplasms
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