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Effect of exogenous mouse interferon on murine fulminant hepatitis induced by mouse hepatitis virus type 2 |
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| Authors: | Dr. Yasuhiro Kato Yatsugi Noda Masashi Unoura Nobuyoshi Tanaka Kenichi Kobayashi Nobu Hattori Kiichi Hatano Shigeyasu Kobayashi |
| Affiliation: | 1. First Department of Internal Medicine, School of Medicine, Kanazawa University, Kanazawa, Japan 2. Department of Virology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan 3. Basic Research Laboratories, Toray Industries Inc., Kamakura, Japan |
| Abstract: | We investigated the effect of exogenous mouse alpha- + beta-interferon produced by mouse L cells on the growth of mouse hepatitis virus type 2 (MHV-2) in the liver, the development of liver cell necrosis, and survival in murine fulminant hepatitis induced by MHV-2. Murine fulminant hepatitis was induced in 4-week-old male ICR mice by intraperitoneal inoculation of MHV-2. Mouse interferon (10(3) IU/mouse/day) was intraperitoneally injected every day. Exogenous mouse interferon suppressed both the growth of MHV-2 in the liver tissue and development of liver cell necrosis, and prolonged the survival. It was also found that the earlier mouse interferon was administered, the greater was the prolongation of survival. |
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