| 三苯氧胺、放线菌素D和肿瘤坏死因子－a对人乳腺癌MCF－7细胞株的体外作用 |
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| 引用本文： | 于长隆. 三苯氧胺、放线菌素D和肿瘤坏死因子－a对人乳腺癌MCF－7细胞株的体外作用[J]. 北京大学学报(医学版), 1995, 0(6) |
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| 作者姓名： | 于长隆 |
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| 作者单位： | 北京医科大学第三医院运动医学研究所 |
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| 摘 要： | 用荧光流式细胞计和细胞簇集试验证实雌激素可促使ＭＣＦ－７细胞进入分裂周期，三苯氧胺作用与雌激素相反。放线菌素Ｄ在达到一定剂量时可直接杀死细胞而非抑制细胞进入分裂周期。肿瘤坏死因子－ａ（ＴＮＦ－ａ）对ＭＣＦ－７细胞作用类似三苯氧胺但效果远明显于三苯氧胺；放线菌素Ｄ对雌激素作用有抑制，但对三苯氧胺和ＴＮＦ－ａ作用无拮抗。
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| 关 键 词： | 他莫昔芬／药理学，放线菌素D／药理学，肿瘤坏死因子／药理学，乳腺肿瘤 |
THE EFFECTS OF TAMOXIFEN,ACTINOMYCIN-D AND TNF-A ON HUMAN BREAST CARCINOMA CELL LINE MCF-7 IN VITRO |
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| Institute of Sports Medicine,The Third Hospital Yu Changlong. THE EFFECTS OF TAMOXIFEN,ACTINOMYCIN-D AND TNF-A ON HUMAN BREAST CARCINOMA CELL LINE MCF-7 IN VITRO[J]. Journal of Peking University. Health sciences, 1995, 0(6) |
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| Authors: | Institute of Sports Medicine The Third Hospital Yu Changlong |
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| Abstract: | y means of fluorescence flow cytometer and cell cluster test,the influence of estrogen,tamoxifen,TNF-a and Actinomycin D on MCF-7 cells was determined.Results showed that estrogen enhanced MCF-7 cells into mi-tosis and tamoxifen inhibits the effect of estrogen;Actinomycin D killed MCF-7 cells rather than inhibited cell growth;TNF-a inhibited MCF-7 cells growth dramatically.The effect of estrogen on MCF-7 cell line disappeared when Actinomycin D coexisted in the medium.There was no antagonism between Actinomycin D and tamoxifen or TNF-a. |
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| Keywords: | Headings Tamoxifen/pharmacol Actinomycin D/pharmacol Tumor necrosis factor/pharmacol Breast neoplysms |
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