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| 人参皂苷Rh2增强紫杉醇诱导Hela细胞的凋亡 | |
| 引用本文： | 焦玉莲,王强修,李建峰,王振华.人参皂苷Rh2增强紫杉醇诱导Hela细胞的凋亡[J].中华肿瘤防治杂志,2006,13(21):1623-1626. |
| 作者姓名： | 焦玉莲 王强修 李建峰 王振华 |
| 作者单位： | 1. 山东省立医院,中心实验室,,山东,济南,250021 2. 山东省立医院,病理科,山东,济南,250021 3. 石河子大学药学院省部共建教育部新疆特种植物药资源重点实验室,新疆,石河子,832002 |
| 摘 要： | 目的:探讨人参皂苷Rh2能否增强紫杉醇诱导Hela细胞的凋亡。方法:应用SRB法检测药物抑肿瘤效应;荧光染色和流式细胞仪检测细胞凋亡;应用金氏公式分析药物间的相互作用。结果:人参皂苷Rh2可浓度依赖性地抑制Hela细胞的增殖,并可协同性地增强紫杉醇对细胞增殖的抑制作用;人参皂苷Rh2可协同性地增强紫杉醇诱导的Hela细胞凋亡,并具有浓度依赖性。结论:人参皂苷Rh2可协同性地增强紫杉醇对Hela细胞增殖抑制作用和诱导凋亡作用。 |
| 关 键 词： | 人参皂苷/药理学 紫杉酚 Hela细胞 细胞凋亡/药物作用 |
| 文章编号： | 1673-5269（2006）21-1623-04 |
| 收稿时间： | 2006-03-20 |
| 修稿时间： | 2006-07-04 |
Ginsenoside Rh2 potentiates paclitaxel-induced apoptosis in Hela cells |
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| JIAO Yu-lian,WANG Qiang-xiu,LI Jian-feng,WANG Zhen-hua.Ginsenoside Rh2 potentiates paclitaxel-induced apoptosis in Hela cells[J].Chinese Journal of Cancer Prevention and Treatment,2006,13(21):1623-1626. | |
| Authors: | JIAO Yu-lian WANG Qiang-xiu LI Jian-feng WANG Zhen-hua |
| Abstract: | OBJECTIVE:To explore whether ginsenoside Rh_2 was able to enhance the paclitaxel-induced apoptosis in Hela cells.METHODS:The inhibitory effect on Hela cells proliferation was detected by SRB assay;Apoptosis was determined via fluorescence staining and flow cytometry;The interaction between ginseng saponin Rh_2 and paclitaxel was analyzed by means of Jin's formulation.RESULTS:Ginsenoside Rh_2 inhibited the Hela cells proliferation in a concentration-dependent manner and synergistically enhanced the inhibitory effect of paclitaxel.Furthermore,ginsenoside Rh_2 was able to synergistically increase the apoptosis induced by paclitaxel in a concentration-dependent way.CONCLUSION:Ginsenoside Rh_2 interacted synergistically with paclitaxel to potentiate its proapoptotic effect on Hela cells. |
| Keywords: | ginsenoside/pharmacology paclitaxel Hela cells apoptosis/drug effects |
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