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Insulin-like growth factor-1 and insulin-like growth factor-binding protein-3 in women with premenstrual syndrome |
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| Authors: | Andrea J Rapkin M.D. Marcelle Cedars M.D. Melinda Morgan Ph.D. Linda Goldman R.N.P. M.N. |
| Affiliation: | aUniversity of California, Los Angeles Medical Center, Los Angeles, California, USA bUniversity of Cincinnati, Cincinnati, Ohio, USA |
| Abstract: | Objective: To determine whether women with premenstrual syndrome (PMS) have aberrations of the GH axis as has been demonstrated in individuals with depression. Design: Prospective trial. Setting: Department of Obstetrics and Gynecology, University of California, Los Angeles. Patient(s): After prospective screening, 32 healthy women with PMS and 32 asymptomatic controls completed the study. Intervention(s): Subjects completed a daily PMS symptom diary and a Beck Depression Inventory. They underwent phlebotomy 5 days and 12 days after the LH midcycle surge, which was identified with the use of a urinary LH detection kit. Main Outcome Measure(s): Serum levels of insulin-like growth factor-1 (IGF-1), insulin-like growth factor-binding protein-3 (IGFBP-3), E2, and progesterone. Result(s): Levels of IGF-1, IGFBP-3, E2, and progesterone did not differ between women with prospectively documented PMS and control subjects. Conclusion(s): Premenstrual syndrome and affective disorder share common symptoms and possibly a common cause. Biochemical markers such as alterations in the somatotropic system often are associated with major depression. Levels of IGF-1 and IGFBP-3 did not differ between women with PMS and control subjects, supporting the concept that PMS and endogenous depression are biologically distinct entities. |
| Keywords: | Premenstrual syndrome premenstrual dysphoric disorder growth hormone insulin-like growth factor-1 insulin-like growth factor-binding protein-3 |
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