糖代谢异常和糖尿病患者血浆纤维蛋白原的观察

目的探讨血浆纤维蛋白原在糖代谢异常和糖尿病患者中的变化。方法对155例糖尿病、糖代谢异常患者和正常对照者进行血浆纤维蛋白原、空腹血糖、总胆固醇、三酰甘油、高密度脂蛋白胆固醇、尿素氮和血肌酐检测。结果糖尿病、糖代谢异常和正常对照组之间纤维蛋白原和三酰甘油在各组之间比较差异有统计学意义(P<0.01或P<0.05);纤维蛋白原的多因素linear regression分析发现空腹血糖、三酰甘油是纤维蛋白原的相关因子(P<0.05)。结论糖尿病和糖代谢异常患者血浆纤维蛋白原升高,而且纤维蛋白原与空腹血糖水平相关。因此,血浆纤维蛋白原升高可能参与糖尿病患者心脑血管疾病的形成。

Research of fibrinogen changes in patients with diabetes mellitus or impaired fasting glucose

Objective To study the change of fibrinogen in patients with diabetes mellitus or impaired fasting glucose(IFG). Methods 155 cases were divided into diabetes mellitus group(DM group),impared fasting glucose group(IFG group) and control group.The levels of fibrinogen, fasting glucose, total plasma cholesterol, plasma triglyceride, high density lipoprotein, blood urinary nitrogen,and plasma creatinine concentration were detected. Results The levels of fibrinogen and plasma triglyceride were significantly different among the three groups (P<0.01 or P<0.05), and fasting glucose and plasma triglyceride were identified as significant and independent risk factors for fibrinogen (P<0.05). Conclusions The level of fibrinogen is increased significantly in DM group and IFG group than that in control group.And fibrinogen is related to fasting glucose. Fibrinogen may take part in the development of cardial-cerebral vascular diseases in patients with diabetes mellitus.