T-cell responses to the Mycobacterium tuberculosis-specific antigens in active tuberculosis patients at the beginning,during, and after antituberculosis treatment |
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| Authors: | Jose Domí nguez,Malú De Souza-Galvã o,Juan Ruiz-Manzano,Irene Latorre,Cristina Prat,Alicia Lacoma,Celia Milà ,Maria Á ngeles Jimé nez,Silvia Blanco,José Maldonado,Neus Altet,Vicente Ausina |
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| Affiliation: | 1. Servei de Microbiologia, Hospital Universitari Germans Trias i Pujol, Fundació Institut en Ciències de la Salut Germans Trias i Pujol, Badalona, Spain;2. Servei de Pneumologia, Hospital Universitari Germans Trias i Pujol, Fundació Institut en Ciències de la Salut Germans Trias i Pujol, Badalona, Spain;3. Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain;4. Ciber Enfermedades Respiratorias, Instituto de Salud Carlos III, Badalona, Spain;5. Unidad de Prevención y Control de la Tuberculosis de Barcelona, Barcelona, Spain;6. Serveis Clínics de Barcelona, Barcelona, Spain |
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| Abstract: | The objectives of the study were to assess the performance of the QuantiFERON-TB Gold In-Tube (QFN-G-IT) and the T-SPOT.TB tests in the immunodiagnosis of active tuberculosis (TB) in adult patients, and to study the T-cell interferon γ (IFN-γ) responses during treatment and in patients who have recovered after curative treatment and self-healed TB patients. When only analyzing patients included at the beginning of treatment, the sensitivity was 83.3% for T-SPOT.TB and 69.4% for QFN-G-IT. In contrast, when evaluating patients during treatment, the sensitivity of the T-SPOT.TB and QFN-G-IT decreased to 69.8% and 48.8%, respectively. The response to the specific antigens increased after finishing the treatment compared with the values during the treatment. The T-SPOT.TB was more sensitive in diagnosing active TB than the QFN-G-IT. The IFN-γ tests could be used as a complementary method in the diagnosis of active TB. |
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| Keywords: | Active tuberculosis Mycobacterium tuberculosis |
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