胸段食管癌TN分期的CT表现与p53蛋白的关系

目的：探讨胸段食管癌TN分期的CT表现与p53蛋白表达之间的关系。方法：利用免疫组织化学（SP）法及CT扫描，分析66例经病理确诊的胸段食管癌组织p53蛋白表达与TN分期的CT表现间的关系。结果：经CT分期，T1期3例，T2期10例，T3期41例，T4期12例，淋巴结转移21例。p53蛋白的阳性表达率为51.52%（34/66）。T4期中p53蛋白的阳性表达率高于T3、T1~2期（χ2分别为3.412、3.381，P值均＜0.05）。淋巴结转移阳性与阴性组中p53蛋白阳性表达率分别为80.95%（17/21）和37.78%（17/45），二者差异有统计学意义（χ2=10.686，P=0.001）。T1~2、T3、T4期p53蛋白高表达率分别为23.08%（3/13）、46.34%（19/41）、66.67%（8/12），p53蛋白表达强度随着CT的T分期升高而有增强的趋势（rs=0.270，P=0.028）。淋巴结短径≤2cm与短径＞2cm组的p53蛋白阳性表达率为84.62%（11/13）、75.00%（6/8），二者差异无统计学意义（P=0.289）。结论：食管癌中较高的p53蛋白表达与CT术前TN分期相关，p53蛋白的表达强度随着CT T分期升高有增强的趋势，淋巴结大小与p53蛋白无关。

The relationship between p53 protein and CT manifestation of the TN-staging in thoracic esophageal carcinoma

Objective:To study the relationship between the CT manifestation of the TN-staging and the expressions of p53 protein in thoracic esophageal carcinoma.Methods:p53 protein expressions in esophageal carcinoma and its relationship with the TN-staging by CT were analyzed by means of SP immunohistochemical technique and CT scanning in 66 patients with esophageal carcinoma proved by pathology.Results:There were 3 cases staged as T1, 10 cases as T2, 41 cases as T3, and 12 cases as T4 by CT.Twenty-one cases were de...