| 氟尿嘧啶半乳糖化白蛋白微球表面性质的研究 |
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| 引用本文： | 余江南,徐希明,张钧寿.氟尿嘧啶半乳糖化白蛋白微球表面性质的研究[J].中国药科大学学报,2000,31(5):35-37. |
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| 作者姓名： | 余江南 徐希明 张钧寿 |
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| 作者单位： | [1]镇江医学院药学系,镇江 [2]中国药科大学药剂学教研室,南京 |
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| 基金项目： | 江苏省社会发展基金!资助项目 (BS98391)，镇江医学院博士科研启动基金!资助项目 (9939) |
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| 摘 要： | 借助漫反射红光谱（ＤＲＩＲ）、Ｘ－射光电子能谱（ＸＰＳ）技术，对自制的氟尿嘧啶半乳糖化白蛋白微球（Ｆｕ－ＧＢＭ）表面的光谱性质进行了研究。解析结果证实：偶联后，Ｆｕ－ＢＭ表层的Ｆｕ被洗脱，Ｆｕ－ＧＢＭ的表面成功地偶联了半乳糖，表面覆盖率为２５．４％。
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| 关 键 词： | 氟尿嘧啶 半乳糖化白蛋白微球 DRIR XPS |
Spectra Charactaristics of Surface of Fluorouracil Galactosyl Albumin Microsphere |
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| YU Jiang-Nan,XU Xi-Ming,ZHANG Jun-Shou.Spectra Charactaristics of Surface of Fluorouracil Galactosyl Albumin Microsphere[J].Journal of China Pharmaceutical University,2000,31(5):35-37. |
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| Authors: | YU Jiang-Nan XU Xi-Ming ZHANG Jun-Shou |
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| Institution: | YU Jiang-Nan,XU Xi-Ming,ZHANG Jun-Shou 1 Department of Pharmacy,Zhenjiang Medical College,Zhenjiang 212001, 1Department of Pharmaceutics,China Pharmaceutical University,Nanjing 210009 |
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| Abstract: | Diffuse reflect infrared(DRIR) and X-ray photoelectron spectroscopy(XPS) techniques were utilized to study the surface properties of fluorouracil bovine serum albumin microspheres(Fu-BM) and fluorouracil galactosyl bovine serum albumin microspheres (Fu-GBM). It is first confirmed that, by analysis of the spectra, 2-imino-2-methoxyethyl-1-thio-galactose(IME-thiogalactose) react successfully with Fu-BM and Fu adsorbed on the surface of Fu-BM is then washed off after the coupling. The covering ratio on the surface of Fu-GBM is 25.4%. |
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| Keywords: | Fluorouracil Galactosyl-bovine serum albumin-microspheres Diffuse reflection infrared spectroscopy X-ray photoelectron spectroscopy |
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