| 肠毒清颗粒对肝硬变内毒素血症大鼠模型内毒素及炎症因子的干预作用 |
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| 引用本文： | 张照兰,;王毓麟.肠毒清颗粒对肝硬变内毒素血症大鼠模型内毒素及炎症因子的干预作用[J].河南中医药学刊,2014(11):1616-1618. |
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| 作者姓名： | 张照兰 ;王毓麟 |
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| 作者单位： | [1]河南中医学院第一附属医院,河南郑州450000; [2]天津市武警医学院附属医院,天津300162 |
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| 基金项目： | 河南省科技厅科技攻关项目（编号0496060401） |
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| 摘 要： | 目的：探讨肠毒清颗粒对大鼠肝硬变内毒素血症的干预作用。方法：70只大鼠分为正常对照组10只，余60只制作大鼠肝硬变模型组。模型制作成功后，分为模型组、肠毒清高剂量组、肠毒清低剂量组、乳果糖治疗组。观察各组大鼠的内毒素、TNF-α、IL-6及NO水平。结果：模型组与正常组比较，血浆内毒素、肝匀浆TNF-α、IL-6及NO水平明显升高（ P〈0.05）；与模型组比较，肠毒清高剂量组、肠毒清低剂量组、乳果糖组大鼠血浆内毒素、肝匀浆TNF-α、IL-6及NO水平明显降低（ P〈0.05）。肠毒清高剂量组与乳果糖组比较，内毒素、TNF-α、IL-6差异显著（ P〈0.05）；与肠毒清低剂量组比较，血浆内毒素、IL-6差异有统计学意义。乳果糖组TNF-α、NO与肠毒清低剂量组比较，有显著性差异（ P〈0.05）。结论：肠毒清颗粒能够防治肝硬变内毒素血症。
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| 关 键 词： | 肠毒清颗粒 肝硬变 内毒素 TNF-α IL-6 NO |
Intervention Effect of Changduqing Granules on Endotoxin and Inflammation Factor of Hepatic Cirrhosis Endotoxemia Rats Model |
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| Institution: | Zhang Zhaolan, Wang Yulin( 1. The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou Henan China 450000 2. Affiliated Hospital of Tianjin Armed Police Medical School,Tianjin China 300162) |
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| Abstract: | Objective：To study the intervention effect of Changduqing Granules on endotoxin and inflammation factor of hepatic cirrhosis endotoxemia. Methods：70 rats were divided into normal control group 10,the others cirrhosis rats model group. After the success of mod-el making,divided into model group,high dose group,low dose group and Lactulose group. Observe the endotoxin in rats,TNF alpha,IL-6 and NO level. Results：Compared with normal group,the plasma endotoxin,liver homogenate TNF-α,IL-6 and NO level of model group were increased significantly（P〈0. 05）. Compared with model group,the rats plasma endotoxin,liver homogenate TNF-α,IL-6 and NO level of high dose group,low dose group and Lactulose group were significantly decreased（P〈0. 05）. Conclusion：Changduqing Gran-ules can control hepatic cirrhosis endotoxemia. |
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| Keywords: | changduqing granules hepatic cirrhosis endotoxin TNF-α IL-6NO |
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