银杏叶萃取物治疗耳鸣临床研究

目的：探讨银杏叶萃取物治疗耳鸣的疗效及安全性。方法：将100例耳鸣患者按照抽签法随机地均分为对照组与观察组，两组均给予5 mg·d-1盐酸氟桂利嗪作为基础治疗药物，对照组加用10 mg维生素B6，每天3次；观察组给予银杏叶萃取物56.7 mg·d-1加用治疗，每天3次，疗程均为30 d。比较两组疗效、耳鸣响度评分（ TVL）、焦虑倾向评分（ SAS）、耳鸣残疾评分（THI）及不良反应发生情况。结果：对照组有效率为74.00%，观察组有效率为92.00%，两组比较差异具有统计学意义（P〈0.01）。对照组治疗后1周、2个月TVL、SAS及THI得分与观察组相比，差异均具有统计学意义（P〈0.05），且两组治疗后1周与2个月上述各指标的变化值差异均具有统计学意义（P〈0.05）。对照组不良反应发生率为14.29%（4/28），观察组为12.00%（3/25），两组比较差异无统计学意义（P＆gt;0.05）。结论：银杏叶萃取物治疗耳鸣疗效显著，耳鸣响度、焦虑情绪及耳鸣致残等方面均有明显改善，且安全性高。

Research on the Ginkgo Biloba Extract in the Treatment of Tinnitus

Objective：To investigate the efficacy and safety of Ginkgo Biloba extract in treating tinnitus. Methods：100 cases of patients with tinnitus were randomly divided into control group and observation group. Both two groups were given 5mg/d flunarizine hydrochlo-ride as basic treatment. The control group was treated with 10mg vitamin B6,3 times a day. The observation group was given Ginkgo Bi-loba extract 56. 7mg/d treatment,3 times a day,a course of 30d. Therapy,tinnitus loudness rating（ TVL）,anxiety propensity scores （SAS）,tinnitus disability score（THI）,and adverse events were compared. Results：The total effective rate was 74. 00% in control group and 92. 00% in observation group,there was a significantly statistical difference between the two groups（P〈0. 01）. There was a statistical difference of 1 week,2 months TVL,SAS and THI scores between the two groups（P〈0. 05,P〈0. 01）. After one week and two months of treatment,each of the above indicators in the value had statistically significant difference（P〈0. 05）. The adverse reac-tions incidence rate was 14. 29%（4/28）in control group and 12. 00%（3/25）in observation group. The difference was not statistically significant（P＆gt;0. 05）. Conclusion：Ginkgo Biloba extract in treating tinnitus,tinnitus loudness,anxiety and other aspects of disability has evident effect with high safety.