中药调节滑膜细胞治疗类风湿性关节炎研究进展

类风湿性关节炎（rheumatoid arthritis,RA）是以滑膜炎为主要特征的慢性、系统性、自身免疫性疾病。该病是临床常见病,病程长、治疗难、易反复,最后导致功能障碍影响生活质量。RA属于中医学＂痹证＂范畴,是由于风、寒、湿邪入侵,导致气血凝滞,经络痹阻而引起的肢体关节病变。往往寒热错杂、虚实同见、痰瘀互结,病程缠绵难愈。近年来滑膜细胞成为中药治疗RA的主要靶向,许多中药通过调节相关因子的表达及分泌直接或间接地作用于滑膜细胞达到治疗RA的目的,临床疗效显著。

Research Progress of Chinese Herbal Regulating Synoviocytes Treatment of Rheumatoid Arthritis

Rheumatoid Arthritis（ RA） is a kind of chronic,systemic,autoimmune disease with synovitis as the main feature. Rheumatoid arthritis is the clinical common disease,the course of a long,difficult treatment and easy repeatedly. Eventually lead to dysfunction affects quality of life. RA belongs to the category of traditional Chinese medicine ＂ Bi zheng＂. The disease is due to invasion of wind,cold,damp,leading to qi and blood stagnation and meridian bizu causes disease of limb joints. Often mixed with cold and heat,combining deficiency and excess,binding of phlegm and stasis,long duration. In recent years,synovial cells become the main target of traditional Chinese medicine treatment of RA,many traditional Chinese medicine（ TCM） by adjusting the expression and secretion of related factors directly or indirectly effect on the synovial cells to achieve the purpose of treatment of RA,and the clinical curative effect is distinct.