In vivo quantitative three-dimensional motion mapping of the murine myocardium with PC-MRI at 17.6 T. |
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Authors: | Volker Herold Philipp Mrchel Cornelius Faber Eberhard Rommel Axel Haase Peter M Jakob |
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Institution: | Department of Experimental Physics 5, University of Würzburg, Würzburg, Germany. vrherold@physik.uni-wuerzburg.de |
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Abstract: | This work presents a method that allows for the assessment of 3D murine myocardial motion in vivo at microscopic resolution. Phase-contrast (PC) magnetic resonance imaging (MRI) at 17.6 T was applied to map myocardial motion in healthy mice along three gradient directions. High-resolution velocity maps were acquired at three different levels in the murine myocardium with an in-plane resolution of 98 mum, a slice thickness of 0.6 mm, and a temporal resolution of 6 ms. The applied PC-MRI method was validated with phantom experiments that confirmed the correctness of the method with deviations of <1.7%. Myocardial in-plane velocities between 0.5 cm/s and 2.2 cm/s were determined for the healthy murine myocardium. Through-plane velocities of 0.1-0.83 cm/s were measured. Velocity data was also used to calculate the myocardial twist angle during systole at different slices in the short-axis view. |
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Keywords: | MRI cardiac motion cardiac function phase contrast myocardial velocity 3D phase contrast high field cardiac trigger |
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