| 超滤法去除中药注射液中的细菌内毒素 |
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| 引用本文： | 尹楠,李红阳,彭国平,郑云枫. 超滤法去除中药注射液中的细菌内毒素[J]. 中国医药工业杂志, 2008, 39(12) |
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| 作者姓名： | 尹楠 李红阳 彭国平 郑云枫 |
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| 作者单位： | 南京中医药大学中医药研究院,江苏,南京,210029 |
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| 基金项目： | 国家科技支撑计划 |
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| 摘 要： | 用动态浊度法定量检测细菌内毒素的含量,以10k及50k截留分子量的超滤膜超滤,评价超滤技术去除三种自制中药注射液中细菌内毒素的效果。结果显示,各药液经超滤后,内毒素的含量均在0.388～0.843EU/ml,内毒素去除效率大于90%。
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| 关 键 词： | 超滤 细菌内毒素 动态浊度法 中药注射液 |
Elimination of Bacterial Endotoxins in Chinese Traditional Medicine Injection by Ultrafiltration Device |
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| YIN Nan,LI Hong-yang,PENG Guo-ping,ZHENG Yun-feng. Elimination of Bacterial Endotoxins in Chinese Traditional Medicine Injection by Ultrafiltration Device[J]. , 2008, 39(12) |
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| Authors: | YIN Nan LI Hong-yang PENG Guo-ping ZHENG Yun-feng |
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| Abstract: | The kinetic-turbidimetric method was used to determine the content of bacterial endotoxins.The elimination effect of bacterial endotoxins in three kinds of Chinese traditional medicine injection with molecular weight cut-off(MWCO) 10k and 50k ultrafitration membrane was discussed.The results showed that the content of bacterial endotoxins was 0.388 -0.843 EU/ml after ultrafitration,and the elimination efficiency of bacterial endotoxins was above 90%. |
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| Keywords: | ultrafiltration bacterial endotoxins kinetic-turbidimetry Chinese traditional medicine injection |
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