Effect of Opiate Peptide Dalargin and Des-Tyr-Dalargin on Cardiac Pump Function during Ischemia-Reperfusion |
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| Authors: | T V Lasukova L N Maslov Yu K Podoksenov A Yu Podoksenov A A Platonov M V Ovchinnikov Zh D Bespalova |
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| Institution: | Laboratory of Experimental Cardiology, Institute of Cardiology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Tomsk. |
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| Abstract: | Experiments on isolated perfused rat heart showed that nonselective micro- and delta-opiate receptor agonist dalargin decreased contractility of the intact heart, but had no effect on pump function of the ischemic myocardium. Dalargin analogue des-Tyr-dalargin not binding to opiate receptors decreased contractility of intact myocardium and isolated heart exposed to 45-min total ischemia. We hypothesize that the influence of dalargin is related to activation of cardiac delta-opiate receptors, while the inotropic effect of des-Tyr-dalargin is mediated by other receptors. |
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| Keywords: | dalargin des-Tyr-dalargin opiate receptors ischemia-reperfusion |
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