1-(4-甲基苄基)-2-甲基-八氢异喹啉盐酸盐的合成

化合物1-(4-甲基苄基)-2-甲基-八氢异喹啉盐酸盐(1)是制备新型镇咳药磷酸二甲啡烷的关键中间体。对化合物1的合成工艺进行研究，以4-甲基苯乙酸为原料，采用氯化亚砜氯代制得4-甲基苯乙酰氯，再与2-环己烯基乙胺反应，再经环化、还原、N-甲基化和成盐酸盐纯化得到目标产物1，总收率约54%，纯度大于98%。该工艺具有原料易得、操作简便、产率和纯度高、成本低等优点，适合工业化生产。

Synthesis of 1-(4-methylbenzyl)-2-methyl-octahydro-isoquinoline hydrochloride

1-(4-Methylbenzyl)-2-methyl-octahydro-isoquinoline hydrochloride(1)is the key intermediate to prepare a new type of antitussives agent phosphate dimemorfan. 4-methyl-phenylacetic acid as a raw materials, was chlorinated with thionyl chloride to obtain 4-methyl-phenylacetyl chloride, followed by reaction with 2-cyclohexenyl amine, then cyclization, reduction, methylation and salt formation by HCl were taken out to give the desired product 1. The total yield is 54%, and the purity is greater than 98%. This synthetic process is characterized with available raw materials, simple in operation with high yield and purity, and suitable for large-scale production.