Hip, an HP1-interacting protein, is a haplo- and triplo-suppressor of position effect variegation |
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Authors: | Schwendemann Alexander Matkovic Tanja Linke Christian Klebes Ansgar Hofmann Annemarie Korge Günter |
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Affiliation: | Institut für Biologie, Freie Universität Berlin, Arnimallee 7, 14195 Berlin, Germany |
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Abstract: | The Drosophila heterochromatin protein 1 (HP1) regulates epigenetic gene silencing and heterochromatin formation by promoting and maintaining chromatin condensation. Here we report the identification and characterization of an HP1-interacting protein (Hip). Hip interacts with HP1 in vitro and is associated with HP1 in vivo. This interaction is mediated by at least three independent but similar HP1-binding modules of the Hip protein. Hip and HP1 completely colocalize in the pericentric heterochromatin, and both haplo- and triplo-dosage mutations act as dominant suppressors of position effect variegation. These findings identify a player in heterochromatinization and suggest that Hip cooperates with HP1 in chromatin remodeling and gene silencing. |
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Keywords: | Drosophila heterochromatin |
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