Effect of amphotericin B on capsule and cell size in Cryptococcus neoformans during murine infection |
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| Authors: | Zaragoza Oscar Mihu Coralia Casadevall Arturo Nosanchuk Joshua D |
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| Affiliation: | Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA. |
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| Abstract: | Antifungal drugs can affect the cellular morphology of Cryptococcus neoformans in culture, which alters its interactions with phagocytes. We examined the effects of amphotericin B on C. neoformans during murine infection. The antifungal reduced capsule size and serum polysaccharide, which suggests an additional mechanism for amphotericin B's efficacy in cryptococcosis. |
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