国产吉西他滨联合顺铂治疗63例晚期非小细胞肺癌的临床观察

目的：评价吉西他滨联合顺铂治疗晚期非小细胞肺癌的疗效和毒性。方法：60例患者采用吉西他滨1000mg／m^2，iv，d1-8顺铂75mg／m^2，iv，d。125mg／m^2，iv，d1-3，化疗。每3周期评价疗效。结果：初治病例RR44．6％，复治病例RR30．8％。主要不良反应为骨髓抑制。结论：吉西他滨联合顺铂冶疗晚期非小细胞肺癌具有较高有效率，毒性可以耐受。

Clinical observation of gemcitabine plus cisplatin in treatment of 63 cases advanced of non-small cell lung cancer

Objective:To evaluate the curative effect and toxicity of gemcitabine combined with cisplatine in treatment of advanced non-small cell lung cancer.Methods:Sixty three cases were treated with gemcitabine1000mg/m2 IV on day 1,8,and cisplatin 75mg/m2 IV on day1 or 25mg/m2 IV on day 1,2,3,repeated every 3 weeks and the clinical response was assesed after three cycles.Results:Effective rate of patients with primary treatment was 44.6%,effective rate of patints previously treated was 30.8%.The principal toxicity was inhibition of bone marrow.Conclusion:Gemcitabine combined with cisplatine shows a better therapeutic effect in treatment of advanced non-small cell lung cancer,and toxicity is tolerant.