| 慢性肾衰大鼠IL－2基因表达的改变及淫羊藿的调节作用 |
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| 引用本文： | 陈香美,廖洪军,李宁虹,卢英杰. 慢性肾衰大鼠IL－2基因表达的改变及淫羊藿的调节作用[J]. 解放军医学杂志, 1995, 0(5) |
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| 作者姓名： | 陈香美 廖洪军 李宁虹 卢英杰 |
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| 作者单位： | 解放军总医院 |
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| 摘 要： | 采用ＭＴＴ掺入法及Ｎｏｒｔｈｅｒｎ杂交技术探讨了慢性肾衰大鼠脾细胞ＩＬ－２水平及其ｍＲＮＡ的表达，以及中药淫羊藿对其影响。结果显示，慢性肾衰大鼠ＩＬ－２ｍＲＮＡ表达量及脾细胞培养上清中ＩＬ－２的水平均低于正常对照组（Ｐ＜０．０５），经中药淫羊羹调节后ＩＬ－２水平及ＩＬ－２ｍＲＮＡ表达可恢复至正常水平。
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| 关 键 词： | Northern杂交；IL－2mRNA表达；肾功能衰竭；淫羊藿 |
EFFECTS OF EPIMEDIUM SAGITTATUM ON GENE EXPRESSION OF IL-2MRNA IN RATS WITH CHRONIC RENAL FAILURE |
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| Chen Xuabgmei,Liao Hong jun, Li Ning hong ,et al. EFFECTS OF EPIMEDIUM SAGITTATUM ON GENE EXPRESSION OF IL-2MRNA IN RATS WITH CHRONIC RENAL FAILURE[J]. Medical Journal of Chinese People's Liberation Army, 1995, 0(5) |
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| Authors: | Chen Xuabgmei Liao Hong jun Li Ning hong et al |
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| Affiliation: | General Hospitalof PLA Beijing 100853 |
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| Abstract: | Using Northern hybridization technique we investigated the expression of IL-2mRNA in spleen cells of rats with chronic renal failure (CRF),as well as the effects of epimedium sagittaum on the levels of serum biochemical parameters IL-2 activity and gene expression Results showed that in rats with CRF,both the amount of IL-2mRNA expression and the level of IL-2 in supernatant of cultured spleen cells were lower than those of normal rats (p<0.05).After epimedium sagittatum treatment ,both the level of IL-2 acitvity and the expression of IL-2mRNA returned to normal Epimedium Sagittatum could also reduce the levels of BIN and serum creatinine It indicated the Chinese herb medicine epimedium sagittatum has some immunoenhancing effects in rat with chronic renal failure . |
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| Keywords: | northern hybridization IL-2mRNA exoression renal failure epimedium sagittatum(EP) |
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