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| 马来酸桂哌齐特的合成工艺研究 | |
| 引用本文： | 张静,瞿小兰,焦明坤,彭洋桥,罗智,项光亚. 马来酸桂哌齐特的合成工艺研究[J]. 中国药师, 2010, 13(5): 656-658 |
| 作者姓名： | 张静 瞿小兰 焦明坤 彭洋桥 罗智 项光亚 |
| 作者单位： | 1. 江西省食品药品检验所,南昌,330029;华中科技大学同济医学院药学院 2. 华中科技大学同济医学院药学院 3. 华中科技;湖北省天然药物资源评价重点实验室 |
| 摘 要： | 目的：对马来酸桂哌齐特合成工艺进行改进。方法：以四氢吡咯和3，4，5-三甲氧基肉桂酸为原料，经过酰化、胺化、氯代、缩合、最后与马来酸成盐等步骤合成马来酸桂哌齐特。结果：所得产物化学结构经核磁共振氢谱及质谱确证，总收率为59．6％；产物纯度经由HPLC法测定含量为99．2％。结论：该合成工艺简便、合理、可行，适于工业化生产。 |
| 关 键 词： | 马来酸桂哌齐特 合成 工艺研究 |
Study on Synthesis Process of Cinepazide Maleate |
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| Zhang Jing,Qu Xiaolan,Jiao Mingkun,Peng Yangqiao,Luo Zhi,Xiang Guangya. Study on Synthesis Process of Cinepazide Maleate[J]. China Pharmacist, 2010, 13(5): 656-658 | |
| Authors: | Zhang Jing Qu Xiaolan Jiao Mingkun Peng Yangqiao Luo Zhi Xiang Guangya |
| Affiliation: | 1. Jiangxi Provicial Institute For Drug And Food Contral, Nanchang 330029, China ;2. TongJi School of Pharmacy, Huazhong University of Science and Technology; 3. Hubei Key Lahoratory of Natural Products Chemistry and Resource Evaluation) |
| Abstract: | Objective： To synthesize einepazide maleate by improved method. Method： Cinepazide maleate was synthesized by five steps operation, nafoxidine and 3,4,5,-trimethoxycinnamylic acid were used as starting material. Result： Chemical structure of the product was comfirmed by H-NMR and MS. Total yield was 59.6%. HPLC determined product＇s contents achieved 99.2%. Conclusion： The operation is suitable for large scale production involving simple reasonable and feasible technique. |
| Keywords: | Cinepazide maleate Synthesis Technology study |
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