肥胖病妇女的脂肪分布与血清脂质成分的相关分析

目的：筛选预示血脂异常的描述中心性肥胖的简易指标。方法：同时测量93例肥胖病妇女的腰围、腹围、臀围、腰围臀围比值（WHR1）和腹围臀围比值（WHR2），并测定血清总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、高密度脂蛋白-2-胆固醇（HDL2-C）、高密度脂蛋白-3-胆固醇（HDL3-C）、低密度脂蛋白胆固醇（LDL-C）和极低密度脂蛋白胆固醇（VLDL-C）。结果：WHR1与血清TG、VLDL-C呈正相关，与HDL-C、HDL2-C呈负相关；剔除年龄、体质量指数（BMI）和臀围的影响后仅WHR1与TG、VLDL呈正相关，WHR1与HDL2-C呈负相关，而腹围、WHR：与各血脂指标的相关关系消失。结论：腰臀比值是影响血清TG、VLDL-C、HDL2-C水平的独立危险因素，应当以腰臀比值，而不是腰围作为描述中心性肥胖的简易指标。

Study of the Relationship between Body Fat Distribution and Serum Lipid in Obesity-Women

Objective: To find a simple index in evaluating dyslipidemia associated with central obesity. Methods: Ninety three female with adiposis were assessed for cholesterol, triglycerides, HDL-C, HDL2-C, HDL3- C , LDL-C and VLDL-C. At the same time the waist circumference was measured from the midpoint between the lower rib and the upper margin of the iliac crest ( waistline 1) and the level of umbilicus(waistline 2). The hip circumference was measured at the greatest girth of the gluteus and waist-to-hipratio (WHR) was calculated (waist circumference/hip circumference). Results: WHR1 was positively associated with serum TG?VLDL-C and negatively associated with HDL- C?HDL2- C. After controlling for age and BMI, WHR1 still showed positive correlation with TG and VLDL and negative correlation with HDL2-C, but the relationships among waistline 2(umbilicus), WHR2 and lipids disappeared. WHR1 showed closer relationship with TG?VLDL- C and HDL2-C compared with waistline1. Conclusion: WHR is an independent factor in assessing serum TG?VLDL-C and HDL2-C level. We suggested WHR instead of waistline as a simple and feasible index for describing central obesity.