氯诺昔康及曲马多用于肠道手术后自控镇痛的比较研究

目的：评价氯诺昔康及曲马多用于肠道手术后患者自控镇痛(PCA)的安全性及有效性。方法：50例在全麻下行肠道肿瘤切除术的患者，随机分为氯诺昔康组(L组)和曲马多组(T组)，每组各25例。将所配制药液注入PCA泵，设定PCA泵给药速率为2ml／11，术毕时启动PCA泵进行镇痛，镇痛完毕后由患者完成对疼痛的评分，并记录发生的副作用。结果：在病人镇痛总体印象评分中，L组镇痛满意的比例略高于T组，但无统计学差异。T组恶心与呕吐的发生率明显高于L组。结论：氯诺昔康用于肠道肿瘤切除术后PCA的效果与曲马多接近，但副作用少，更适用于急性疼痛的治疗。

Comparison of Patient- controlled Analgesia With Lornoxicam Versus Tramadol in Patients Undergoing Intestinectomy

Objective:To assess the analgesic efficacy and safety of p ati ent-controlled analgesia with lornxicam or tramadol in patients undergoing intes tinectomy.Methods:50 patients scheduled for intestinectomy under general anesthe sia were randomly allocated to lornoxicam(Group L) and tramadol (Group T) for po stoperative patient-controlled analgesia(PCA). Efficacy was assessed by a 5-poin t verbal rating scores of pain intensity. Possible adverse events were also reco rded.Results:Statistical analysis revealed no significant difference in a 5-poin t verbal rating scores of pain intensity between lornoxicam and tramadol.Lornoxi cam caused fewer side effects such as nausea and vomiting than tramadol.Conclusi on:Lornoxicam offers a useful alternative to tramadol with less side effects fo r the patient-controlled analgesia of postoperative pain.