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Real-time multiprocessing of slit scan chromosome profiles |
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| Authors: | P. Zuse R. Hauser R. M nner M. Hausmann C. Cremer |
| Affiliation: | a Institute of Applied Physics, University of Heidelberg, Albert Ueberle Straße 3-5, D-6900, Heidelberg, Germany b Physics Institute, University of Heidelberg, Philosophenweg 12, D-6900, Heidelberg, Germany c Interdisciplinary Center for Scientific Computing (IWR), University of Heidelberg, Im Neuenheimer Feld 368, D-6900, Heidelberg, Germany |
| Abstract: | The multiprocessor NERV and its application to slit scan flow cytometry is described. Up to 320 processors and 640 MBytes of RAM may be used in one VME crate, providing a computing power of ≤ 1300 MIPS. The multiprocessor is controlled by a host computer that provides a friendly user interface and comfortable program development tools. All hardware and software has been tested on a prototype NERV system with 5 processors. For a real-time classification/detection of normal and aberrant chromosomes, the centromeric index or the number of centromeres are computed or specifically labeled DNA sequences are detected. The program is partitioned into 60 tasks that can be executed concurrently. A total analysis time of < 600 μs including system overhead will be achieved according to timing measurements which have been done for all individual tasks. |
| Keywords: | Author Keywords: MIMD (multiple instruction stream multiple data stream) Computer architecture Parallel processing NERV Real-time chromosome classification Slit scan flow cytometry Biological dosimetry |
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