| 酪氨酸激酶受体B与脑源性神经营养因子mRNA在鼻咽癌中的定量表达 |
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| 引用本文： | 温文胜,张哲,谢莹,易翔,赵卫民,徐志文,唐安洲,黄光武.酪氨酸激酶受体B与脑源性神经营养因子mRNA在鼻咽癌中的定量表达[J].中国耳鼻咽喉头颈外科,2009(7):376-379. |
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| 作者姓名： | 温文胜 张哲 谢莹 易翔 赵卫民 徐志文 唐安洲 黄光武 |
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| 作者单位： | 广西医科大学第一附属医院耳鼻咽喉头颈外科;武警广西总队医院耳鼻咽喉科; |
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| 基金项目： | 广西自然科学基金项目资助(桂科自10728120) |
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| 摘 要： | 目的研究酪氨酸激酶受体B（tyrosine kinase receptors B，TrkB）及其配体脑源性神经营养因子（brain derived neurotrophin factor，BDNF）在鼻咽癌中的表达及其与鼻咽癌生物学行为的关系。方法采用实时荧光PCR的方法对57例鼻咽癌组织、20例鼻咽炎性黏膜组织中的TrkB、BDNF进行检测。结果实时荧光PCR结果为TrkB、BDNF在鼻咽癌组织中表达显著高于鼻咽炎性黏膜组织（P〈0．05）。TrkB表达随鼻咽癌临床浸润程度的升高，淋巴结转移的发生而上调（P〈0．05）。BDNF在有淋巴结转移者显著高于无淋巴结转移者（P〈0．05）。TrkB的表达强度与BDNF有正相关的关系（rs=0．281，P〈0．05）。结论表明TrkB和BDNF在鼻咽癌的浸润和转移机制中起着重要作用，特异性阻断TrkB／BDNF信号传导通路，将为临床治疗鼻咽癌找到新的突破点。
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| 关 键 词： | 鼻咽肿瘤 逆转录聚合酶链反应 脑源性神经营养因子 受体 trkB |
Detection of TrkB and BDNF gene expression in nasopharyngeal carcinoma by real-time RT-PCR |
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| WEN Wensheng,ZHANG Zhe,XIE Ying,YI Xiang,ZHAO Weimin,XU Zhiwen,TANG Anzhou,HUANG Guangwu.Detection of TrkB and BDNF gene expression in nasopharyngeal carcinoma by real-time RT-PCR[J].Chinese Archives of Otolaryngology-Head and Neck Surgery,2009(7):376-379. |
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| Authors: | WEN Wensheng ZHANG Zhe XIE Ying YI Xiang ZHAO Weimin XU Zhiwen TANG Anzhou HUANG Guangwu |
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| Institution: | WEN Wensheng~1,ZHANG Zhe~1,XIE Ying~1,YI Xiang~1,ZHAO Weimin~2,XU Zhiwen~1,TANG Anzhou~1,HUANG Guangwu~1 (1 Department of Otolaryngology Head and Neck Surgery,the First Affiliated Hospital of Guangxi Medical University,Nanning,Guangxi,530021,China,2 Department of Otolaryngology,Guangxi Municipal Corps Hospital,Chinese People's Armed Police Forces,530007,China) |
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| Abstract: | OBJECTIVE To study the expression of tyrosine kinase receptors B(TrkB) and its ligand brain derived neurotrophin factor(BDNF) in nasopharyngeal carcinoma(NPC) and to evaluate the relationship between the expression of TrkB,BDNF and biological behavior of NPC.METHODS The expression of TrkB and BDNF were studied by Real-time PCR analysis in 57 NPC tissues and 20 nasopharyngeal inflammation tissues.RESULTS Expression of both TrkB and BDNF were significantly higher in NPC tissues than that in inflammation tissu... |
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